About our group
The Mass Spectrometry of Biopolymers (BioMS) service facility provides a rich set of techniques for bottom-up, top-down and structural analysis of proteins and other biomolecules.
We offer identification and quantification of proteins from various biological samples, including cell or tissue lysates, immunoprecipitates (IPs) or SDS-PAGE bands. We perform quantification of proteins using both label-free approaches and labeling strategies like TMT. We perform post-translational modification analysis, including phosphoproteomics.
Additional services provided include denaturing intact mass analysis for protein mass confirmation and study of covalent modifications or complexes. Native mass spectrometry for exploring protein and protein-ligand non-covalent interactions and assemblies, crosslinking mass spectrometry for mapping protein interfaces and topologies, and hydrogen-deuterium exchange mass spectrometry for investigating conformational dynamics and protein and ligand binding locations. We also offer ion mobility measurements to analyze shape differences between populations of isobaric molecules in the sample or of the same molecules at different conditions.
We provide consultation, sample workflow optimization, and perform the data analysis. We further support research with data deposition into public repositories, assist with figure creation, and general manuscript preparation.
You can find more information on individual analysis types available on the Service page.
To submit a service request, use the (soon-to-be replaced) ReQuest system.
